Lab-on-a-Chip

Lab-on-a-Chip

The Lab-on-a-Chip strategic research field devises technology-based solutions for problems concerning analysis and synthesis in the fields of biomedicine, environment, and energy. Analysis of real-world samples typically calls for laborious and time consuming sample preparation prior to analyte detection. Many sample preparation schemes have been established for conventional laboratory analysis but few have been transferred to the emerging field of miniaturised chip devices. The Lab-on-a-Chip field has a strategic aim of on-chip integration of the detection system as well as most or all sample preparation to produce autonomous, reliable, self-contained, and cost-efficient devices.

 



Research areas:

Lab-on-a-chip technology

Lab-on-a-chip technology
With a strong foundation in the unique micro- and nanofabrication facilities of DTU Danchip, we are constantly improving and expanding the range of LOC technologies.
Most of the department’s research groups have activities in the LOC field, covering applications in patient sample analysis,
drug screening, organs-on-chips for personalised medicine, as well as field-deployable systems for detection of pathogens, illicit compounds, and environmental toxins. Structured, pyrolised carbon is a recently introduced material with a growing number of applications, which we use in addition to well-established methods for producing micro- and nanostructured polymer materials.

3D printing

3D printing
We have a strategic interest in emerging 3D microprinting technologies to enable applications in 3D cell culture for in vitro diagnostic models and patient care.
Our main materials focus is on soft water-filled polymer materials (hydrogels) that more accurately match the biological microenvironment. We develop and employ high-resolution 3D printing methods and tailor-made materials in 3D cell culture models, while attentive to the later need for upscaling of the printing processes. Polymer materials with tunable mechanical properties or integrated components for analysing biological responses are of particular interest.

Sample preparing

Sample preparation
Analysis of real-world samples is difficult due to complex sample handling and purification.
We pursue solutions for fully integrated sample handling to produce autonomous, accurate, self-contained, and cost efficient chip systems. One example is the supported liquid membrane (SLM) extraction based on selective diffusion of analytes from aqueous donors to acceptors over an organic liquid. The organic liquid is held in place by a nanoporous polymer membrane (the SLM). The developed solutions make use of the department’s fabrication strengths in mass producible structured polymers to integrate sample preparation in an industrially scalable process.

Contact

Jenny Emnéus
Professor
DTU Nanotech
45 25 68 67
Niels Bent Larsen
Professor
DTU Nanotech
45 25 81 61