Blood brain barrier

Lundbeck grant for continued research on the blood-brain barrier and drug delivery

torsdag 25 okt 18
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Kontakt

Thomas Lars Andresen
Professor
DTU Nanotech
25 37 44 86

Kontakt

Kasper Bendix Johnsen
Postdoc
DTU Nanotech
45 25 81 37

Professor Thomas L. Andresen’s research group at DTU Nanotech is part of a research team, which has just received funding for continuing their work on transport of large molecules from the blood to the brain.

Professor Thomas L. Andresen’s research group at DTU Nanotech is part of a research team, which has just received funding for continuing their work on transport of large drug molecules to the brain.

The team is headed by Professor Martin Lauritzen, University of Copenhagen, and includes research groups from University of Copenhagen, Aarhus University, Aalborg University, and Technical University of Denmark.

The project started five years ago, where the research team was awarded a grant of 60 MDKK from the Lundbeck Foundation. Now additional 24 MDKK has been granted from the foundation to the research team to develop their work even further in the coming years.

So far, the project has provided valuable insights into the drug transport mechanisms of the blood-brain barrier, which can be described as a semipermeable membrane that separates the circulating blood from the brain. The blood-brain barrier only lets relatively small molecules through, thereby making many potentially efficient types of drugs useless because they cannot cross the barrier.

Actually breaking through the barrier and deliver biologically based drugs to the sick part of the brain can have major significance for neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. The project also provides important knowledge on how to design new drugs, and how to deliver the right dosage, at the right time, in the right place. All vital factors for developing efficient treatment.

DTU Nanotech’s role in the project is to develop the drug delivery systems. Previously, nanoparticles for transportation of drugs into the brain have been developed successfully, and in the coming years other modes of drug transportation from the bloodstream to the brain will be investigated.

Read more about the new grant here: https://news.ku.dk/all_news/2018/10/research-team-receives-new-funding-for-continued-research-into-the-blood-brain-barrier/ 

Read more about the project here: http://www.ribbdd.dk/

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