Bioinspired Nanomaterials

Therapeutic Nanobiocatalysis

Nanotechnology is changing the healthcare, environment and functional materials landscape, and we are witnessing a rise in the application of nanoscale phenomena to the development of new therapeutics. Nanobiocatalysis generally describes the incorporation of enzymatic behaviour into nanostructured materials. The large surface-to-volume ratio of nanomaterials allows the incorporation of multiple enzymes or catalytic domains on their surface. Nanoparticles can be further functionalized to encapsulate catalytic domains, protecting the active site, and can also be targeted to specific locations within the body. Our group is interested in using programmable nanochemistry and nanobiocatalysis as a new mode of therapy where disease causing substrates and molecules are destroyed in situ through the action of biodegradable nanobiocatalysts. By tapping into innate biological pathways for therapeutic inspiration, we design and synthesize nanobiocatalysts for the treatment of complex inflammatory diseases such as atherosclerosis. Our research is highly interdisciplinary, spanning synthetic chemistry, polymer and materials science, and in vitro and in vivo biological investigations. 



In the news:

  • Nanodroner til kamp mod åreforkalkning (in Danish)
    Forestil dig, at sylespidse krystaller har sat sig fast i dine blodårer og stikker hul i dem på indersiden, så der opstår betændelse, som kan medføre hjerteanfald. Forestil dig så, at man sender bittesmå droner ind i årene for at bekæmpe krystallerne og behandle infektionen. Det er ikke science fiction, det er science.
  • Battling heart disease using nanomedicines
    Cardiovascular disease and related complications are the cause of 40 percent of all deaths in the Western world.


Nazila Kamaly
DTU Nanotech
45 25 81 52