Seeing is believing - Nanoscale Imaging of Biological, Chemical, and Physical Processes
Biologists, chemists and physicists lack tools to observe the ubiquitous processes in liquids with nanoscale resolution. Our work aims at developing novel tools based on micro and nanofabricated devices for high resolution imaging with light and electron microscopes to provide new insights into biological, physical and chemical processes.
One part of our work is to develop systems for in-situ TEM studies of nanoscale processes. We work on gas phase reactions on microfabricated heaters and novel chips systems to image processes in liquids. Another part of our work is exploring interactions between cells and nanostructures. We are developing focused ion beam milling combined with scanning electron microscopy to provide 3D images of cells based on standard and cryogenic fixation methods.
It is always possible to do a student project within these research areas. We have posted several suggestions for student projects in the DTU database
Recent publications and news
Ongoing Research Projects:
FTP Sapere Aude project Liquid EM on Imaging nanoscale processes in liquids with electron microscopes (1.1.12-31.12.16).
Environmental electron microscopy methods have been developed for mainly studying gas phase reactions, but live imaging of processes in the liquid phase is lagging behind. We are developing microfluidic system with thin membrane windows that are transparent to the electron beam in SEM and TEM. Combining these windows with the diverse functionality of microfluidic chip systems makes it possible to obtain electron microscopic images with nanoscale resolution in liquids to study numerous processes under controlled conditions, such as biological, chemical and electrochemical processes.
FTP Project “Nano-Live” on Imaging Nanoelectronics Live by Transmission Electron Microscopy:
We are working on methods that allow In-situ TEM of nanoelectronics. We follow the creation of nanodevices in-situ TEM by VLS nanowire growth, and also the processes taking place in nanodevices with nanowires during use. Danish Research Counsil for Technology and Production Case No. 10-082797
EU project FP7-Nanolyse - Nanoparticles in Food: Analytical methods for detection and characterisation:
In our part of this EU project we work on imaging nanoparticles in food.
Studying cells interactions with nanostructures by focused ion beam (FIB-SEM) slice-and-view imaging to create 3D reconstructions for the complex biological processes.
Measurment and characterization of Aerosol particles to assess their toxicological effect in the working environment
EU project FP7-Technotubes on Technology for Wafer-Scale Carbon Nanotube Applications.
Creation of nanotube electrodes of cellular measurements and characterization of the cell-nanotube interface. (2009-2012)Grant agreement no.: CP-IP 228579-1.
Please contact the group leaderKristian Molhave, ---,mobile phone 0045 2512 6672.